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CRAB Drugs Verses LDN


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MS CRABS Verses LDN Side Effects


Side Effects of Multiple Sclerosis Medications



Disease-modifying medications for multiple sclerosis (MS) can have significant side effects.

Interferon beta (Betaseron, Avonex, Rebif)

Side effects of treatment with interferon beta-1a (Avonex and Rebif) and interferon beta-1b (Betaseron) include:

  • Flulike symptoms (such as fatigue, chills, fever, and muscle aches) for 1 to 2 days after an injection. These symptoms, which can be debilitating for some people, often stop after 2 to 3 months of treatment. Taking a pain reliever such as ibuprofen or acetaminophen just before and after each injection may help reduce these symptoms.
  • Redness, swelling, or tenderness at the injection site. This is more common with Betaseron and Rebif. Taking a nonprescription pain reliever just before or after an injection can reduce this side effect.
  • Depression, anxiety, confusion, and eating and sleeping disturbances. These are not very common and may be related as much to MS as to the treatment. Talk to your doctor if these symptoms last more than a day or two.

Glatiramer acetate (Copaxone)

Side effects of glatiramer acetate (Copaxone) may include:

  • Pain, redness, or swelling at the injection site (this occurs in most people).
  • Flushing.
  • Chest pain, rapid heartbeat, and shortness of breath.
  • Anxiety.
  • Tightness in the throat.

These side effects are rarely serious and usually go away on their own shortly after the injection. You may have one or several brief episodes of these effects during the course of treatment with glatiramer acetate.

Side Effects and Cautionary Warnings For LDN


Side effects:

LDN has virtually no side effects. Occasionally, during the first week's use of LDN, patients may complain of some difficulty sleeping. This rarely persists after the first week. Should it do so, dosage can be reduced from 4.5mg to 3mg nightly.

Cautionary warnings:

Because LDN blocks opioid receptors throughout the body for three or four hours, people using medicine that is an opioid agonist, i.e. narcotic medication — such as Ultram (tramadol), morphine, Percocet, Duragesic patch or codeine-containing medication — should not take LDN until such medicine is completely out of one's system. Patients who have become dependant on daily use of narcotic-containing pain medication may require 10 days to 2 weeks of slowly weaning off of such drugs entirely (while first substituting full doses of non-narcotic pain medications) before being able to begin LDN safely.

LDN should probably not be taken during pregnancy until research into that question is completed.

Full-dose naltrexone (50mg) carries a cautionary warning against its use in those with liver disease. This warning was placed because of adverse liver effects that were found in experiments involving 300mg daily. The 50mg dose does not apparently produce impairment of liver function nor, of course, do the much smaller 3mg and 4.5mg doses.

People who have received organ transplants and who therefore are taking immunosuppressive medication on a permanent basis are cautioned against the use of LDN because it may act to counter the effect of those medications.



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